Formulation Optimization of Arecoline Patches
The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux.The Wick Trimmer patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 ROM Handle (PVP), plasticizers (PEG